Cisplatin kidney function
WebFindings: In vivo, after celastrol treatment, cisplatin-induced kidney injury was significantly ameliorated as shown by the improvement of renal function (BUN, serum creatinine, and cystatin C), kidney morphology (PAS staining) and oxidative stress (MDA) and the suppression of renal tubular injury markers of KIM-1 and NGAL. WebSep 2, 2024 · The same protective function could also be found with the expression of Nox4 and Sod2 mRNA (Figures 5D,E). To evaluate the ROS level in the cells, a DHE fluorescent probe was used. ... MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 …
Cisplatin kidney function
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WebSep 1, 2014 · Acute kidney injury (AKI), previously called acute renal failure (ARF) , is defined as an abrupt onset of renal dysfunction ranging from minor loss of function to failure [7,8,9]. AKI is a common clinical complication that develops in approximately 4%–7% of hospitalized patients each year and the prognosis can be poor [ 10 , 11 ]. WebAug 15, 2024 · Among nephrotoxic agents that cause AKI, cisplatin is a chemotherapeutic drug that has been extensively used for treating solid cancers including breast, pancreatic, colorectal, esophageal, blood, lung, bladder, and hepatocellular cancers (Holditch et al., 2024; Rottenberg et al., 2024).
Webcisplatin and kidney dysfunction. Went for my second cisplatin chemo session for SCC of tonsil today (radiation concurrent) but was told that my kidney function had deteriorated … WebJan 3, 2024 · Assessment of kidney function; Bleomycin-induced lung injury; Chemotherapy and radiation-related hemorrhagic cystitis in cancer patients; …
WebCisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, … WebJul 5, 2024 · Cisplatin may reduce the ability of the kidneys to excrete the medicines bleomycin and methotrexate and so may increase the risk of side effects from these medicines. Cisplatin may lower the...
WebRenal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin.
greeny supportWebJan 12, 2011 · Since its introduction into clinical trials, cisplatin (cis-diammine-dichloro-platinum) has had a major impact in cancer medicine, changing the course of therapeutic management of several tumors, such as those of ovary, testes, and the head and neck. fob for accessWebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. fob for electric gatesWebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases. fob for automatic garage doorWebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National … greeny stickum capsWebcisplatin; kidney toxicity; redox imbalance; mitochondria; natural products; oxidative stress 1. Introduction Cisplatin is a widely used anti-solid tumor drug that can target a variety of cancers including those of the breast, ovary, lung, testis, head, and neck [ 1, 2, 3, 4, 5 ]. greeny tableWebMar 23, 2024 · Here, we postulated that systemically delivered rapamycin perfluorocarbon nanoparticles (PFC NP) could reach the injured kidneys at sufficient and sustained concentrations to mitigate cisplatin-induced acute kidney injury … fob for apple watch