Cisplatin kidney toxicity

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August undefined, 2024

WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically … WebHowever, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicity involve oxidative stress, inflammation, and renal fibrosis, which are covered in …

Cisplatin nephrotoxicity - PubMed

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebOct 7, 2024 · 3. Cisplatin Nephrotoxicity. Experimental nephrotoxicity, first reported in 1971 [], is the most frequently studied cisplatin side effect.Over the past decades, researchers have demonstrated that cisplatin can cause nephrotoxicity or acute kidney injury (AKI) of varying severity in a dose-dependent manner [].Depending on the dose (single or … churchdevelopment.com

Cisplatin nephrotoxicity - UpToDate

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebAbstract Renal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin. WebSep 1, 2024 · Rucaparib was the most potent radiosensitiser and VE-821 was the most potent chemosensitiser. VE-821, PF-47736 and MK-1775 attenuated cisplatin-induced S-phase arrest but tended to increase G2 phase accumulation. In mice, cisplatin-induced acute kidney injury was associated with oxidative stress and PARP activation and was … church destroyed by tornado in alabama

Determining the Potential of DNA Damage Response (DDR) …

Significance of downregulation of renal organic cation transporter ...

WebMar 2, 2024 · Cisplatin is a potent anticancer drug widely used for the treatment of several malignant tumors. One of the most relevant side effects of cisplatin is nephrotoxicity, that is very well-known since its introduction in 1978 and limits its use and efficacy [ 1, 2 ]. WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various … deutsche bank art collection jobsWebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential … deutsche bank apprenticeship programme

"WebIntroduction. Cisplatin (cis-diamminedichloroplatinum(II)) is one of the most widely used first-line chemotherapeutic agents for a broad range of cancers.Cisplatin continues to be in widespread clinical use for various solid tumors such as ovarian, testicular, bladder, head and neck, and non-small cell lung cancers 1,2 but its usefulness is limited due to its high … " - Cisplatin kidney toxicity

Cisplatin kidney toxicity

WebCisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after … WebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for patients with eGFR from 50 to 59.9 mL/min may result in a higher cumulative dose of cisplatin without higher renal toxicity, whic …

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WebAug 1, 2024 · Cisplatin can also cause direct nephrotoxicity as it accumulates within the renal epithelial cells leading to DNA damage and release of damage associated molecular patterns (DAMPs). As a consequence, cytokines and inflammatory cells are …

WebApr 12, 2024 · Evaluation of the effect of glycine infusions on the early renal uptake of cisplatin. Kidney platinum content was markedly lower in rats who had received glycine infusion compared to control rats who had received saline-infusion. ... Klastersky, J. Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin … WebWARNING: Cisplatin may cause severe kidney problems, nerve problems, and severe nausea and vomiting. Nerve problems may occur during treatment or weeks after …

WebAug 5, 2024 · However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicity involve oxidative stress, inflammation, and renal fibrosis, which are covered in this short review. WebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known …

WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with …

WebMay 18, 2024 · The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic … church development fund californiaWebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also … deutsche bank apprenticeshipsWebCisplatin is a potent tubular toxin with a high incidence of nephrotoxicity. Carboplatin is considered less nephrotoxic but can still cause tubular injury and interstitial nephritis in patients who have been previously treated with cisplatin. church development services llcWebNov 26, 2024 · In this way, HO-1 expression has been effectively described as a modulator of cisplatin-induced renal toxicity and its increase as a potential approach for decreasing kidney injury [49,50]. As described in these works, rectal O 3 /O 2 insufflation at appropriated concentrations enhances the antioxidant mechanisms in renal tissue, which … church development planWebMay 18, 2024 · The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic … deutsche bank area servedWebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. … church development services virginia beach vaWebMar 22, 2024 · They exert their main toxic effect within the tubular cell by altering phospholipid metabolism. In addition to their direct effect on cells, aminoglycosides cause renal vasoconstriction. The 2... deutsche bank at1 coupon