Cisplatin mitochondria

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August undefined, 2024

WebMitochondria do not have NER mechanisms for mtDNA. We demonstrate that cisplatin forms adducts with mtDNA in DRG neurons, and that this alters mtDNA replication and transcription. The resultant cisplatin-induced mitochondrial dysfunction may lead to a novel mechanism of cisplatin neurotoxicity. WebMore functional mitochondria in cisplatin-resistant compared with cisplatin-sensitive cells were associated to enzymatic changes affecting either the electron transport chain (SKOV-3/SKOV-3-R model) or mitochondrial coupling (COV-362/COV-362-R model).

Mitochondria-Localized Fluorescent BODIPY-Platinum …

WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), which is used primarily for the treatment of DM. WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … on the waves line dance pdf

The cardioprotective effect of human glucagon-like peptide-1 …

WebMay 7, 2024 · Meanwhile, cisplatin causes nuclear and mitochondrial DNA damage, which activates peroxisome proliferator-activated receptor-γ coactivator-1α and increases transcription factor A (TFAM) expression. TFAM transposition to the mitochondria leads to mitochondrial biosynthesis and activation, thereby increasing mitochondrial ROS and … WebJul 5, 2024 · Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. WebNov 7, 2024 · Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Patients with high-grade serous ovarian … on the waves lotion

Mitochondrial Involvement in Cisplatin Resistance - PubMed

A mitochondria-targeted fluorescent probe for cisplatin - Phys.org

WebCisplatin is a platinum-based chemotherapeutic agent that induces peripheral neuropathy in 30% of patients. Peripheral neuropathy is the dose limiting side effect, which has no preventative therapy. We have previously shown that cisplatin induces apoptosis in dorsal root ganglion (DRG) sensory neuro … on the waves bath and body works sprayWebApr 11, 2024 · Introduction. Ovarian cancer (OC) is a lethal gynecological malignancy. Most OC patients benefit from initial treatments with cytoreductive surgery followed by cisplatin (CP)-based chemotherapy 1.However, approximately 70% of OC patients relapse and develop drug-resistance after long-term use of CP 2.Multilayer alterations have been … ios garageband import midi

"WebNov 19, 2013 · Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is … " - Cisplatin mitochondria

Cisplatin mitochondria

Liu Jun Zi Tang-A Potential, Multi-Herbal Complementary Therapy …

WebJul 14, 2024 · Here we have extended this strategy by coordinating in the axial positions of kiteplatin ( [PtCl₂ ( cis -1,4-DACH)], DACH = Diaminocyclohexane) and its CBDCA (1,1-cyclobutanedicarboxylate) analogue the antioxidant α-Lipoic acid (ALA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase (PDK). WebKey results: We demonstrated that the prominent mitochondrial fragmentation occurred in experimental models of cisplatin-induced nephrotoxicity, which was coupled to radical oxygen species (ROS) overproduction, deterioration of mitochondrial function, release of apoptogenic factors and the consequent apoptosis.

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Web2 days ago · Complex 37 and, above all, 38, were the most effective, but the latter led to higher activated Pt content inside the cells (probably because of its greater reduction rate), as well as inside the mitochondria, compared with complex 37 and cisplatin. To explore the mitochondrial effect caused by complexes 37 and 38, the level of mitochondria ... WebOct 29, 2024 · Cisplatin induced mtDNA leakage into the cytosol-probably through BCL-2-like protein 4 (BAX) pores in the mitochondrial outer membrane-in tubules, with subsequent activation of the cGAS-STING...

WebThe additive effects of metformin on cisplatin-induced inhibition of cell proliferation were attenuated under hypoxic conditions, while metformin compromised mitochondrial structure and function. Additional studies are needed to determine the efficacy of this drug combination in vivo. Publication types Research Support, Non-U.S. Gov't MeSH terms WebAug 30, 2024 · Both cisplatin and IFT88-KD caused primary cilia shortening, downregulated mitochondrial oxidative phosphorylation capacity, and had defective fatty acid oxidation and decreased ATP production. Furthermore, IFT88 overexpression enhanced mitochondrial respiration, which partially counteracted cisplatin-induced defective fatty …

WebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis. WebFeb 11, 2015 · cisplatin mitochondria imaging Supporting Information Details of chemical synthesis, structural analysis, and biological assays. This material is available free of …

WebJul 1, 2024 · Background: Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment strategies are urgent.

WebMay 10, 2024 · Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common … ios games like the roomWebNational Center for Biotechnology Information on the way amazonWebNational Center for Biotechnology Information on the waves dance countryWebA study in Chinese hamster ovary cells demonstrated that the proportion of adducts of cisplatin on mitochondrial DNA was four to six times higher compared to nuclear DNA by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA) and immunoelectron microscopy (Olivero et al., 1995; Jamieson and Lippard, 1999). ios garageband with keyboardWebJul 7, 2014 · A mitochondria-targeted Pt(IV)-prodrug of cisplatin, Platin-M, was designed by introducing two mitochondria-targeting delocalized lipophilic TPP cations in the axial positions (Fig. 1A). Recently, a Pt(II) … ios geocaching appWebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as ovarian, colorectal, prostate, lung, and... ios game that support controllerWebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell... on the waves line dance