WebInducers of CYP2B forms include phenobarbitone and 1,1,1-trichloro-2,2-bis (4-chlorphenyl)ethane (DDT) whereas CYP3A form inducers include pregnenolone-16α-carbonitrile and dexamethasone. WebCytochrome P450 3A (including 3A4) inhibitors and inducers. For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation. These classifications are based upon US ...
Frontiers Computational pharmacology and computational …
WebThis is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes . Enzyme. Inhibitors. Inducers. CYP1A1. Certain foods (e.g., cumin, … WebSep 1, 2008 · CYP3A4 Substrates Producing Potentially Serious Toxicity When Combined with CYP3A4 Inhibitors Drug Potential Toxicity Alfuzosin (Uroxatral) Severe hypotension Alprazolam (Xanax) Excessive CNS depression Budesonide Cushing's syndrome Carbamazepine (Tegretol) Vomiting, headache, dizziness, drowsiness Colchicine highlight an entire row based on one cell
Table of Substrates, Inhibitors and Inducers
WebCYP3A4 inhibitors/inducers Ceritinib Antivirals (e.g. ritonavir), macrolide antibiotics (e.g. telithromycin), antifungals (e.g. ketoconazole) and nefazodone Rifampicin Carbamaze … WebIn vitro, remdesivir is a substrate for CYP2C8, CYP2D6, and CYP3A4, and an inhibitor of CYP3A4, as well as a substrate for p-glycoprotein and organic anion transporting polypeptides 1B1 (OATP1B1 ... WebThe cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies and toxic compounds in the environment. The inhibition and induction of CYPs are major mechanisms causing pharmacokinetic dru … highlight analyse cad