Podxl endothelial

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August undefined, 2024

WebPodocalyxin (PODXL) is a mucin protein of the CD34 family expressed in kidney glomerular podocytes, vascular endothelium, progenitor bone marrow and tumor cells. It is assumed …

Podocalyxin in Normal Tissue and Epithelial Cancer - MDPI

WebDec 1, 2024 · Podocalyxin (PODXL), also known as TRA-1-60 and TRA-1-81 antigens, is a highly N - or O-glycosylated type I transmembrane protein with a molecular weight of 150,000–200,000 [[1], [2], [3], [4]], and is used as pluripotent stem … WebCD34 family proteins are expressed by endothelial cells and hematopoietic precursors. PODXL is well known to be associated with invadopodia formation and to promote the epithelial-mesenchymal transition, tumor migration and invasion. PODXL expression was correlated with poor survival of cancer patients. However, the role of PODXL2 in cancer … miners bay trading post

Podocalyxin enhances the adherence of cells to platelets

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebJan 10, 2024 · Podxl is expressed outside the kidney within vascular endothelial cells 5, megakaryocytes 6, hematopoietic stem cells 7, and mesothelial cells that line organs 3 and neurons 8. Web(C) Line-scan of marker intensity from the luminal space of the vessel outwards; isolectin (green, endothelial), PODXL (red, apical), β1 integrin (blue, basal), dextran perfusion (D488, purple, patent lumen), and DAPI (black, nuclear). Black arrows, intensity peaks corresponding to apical and basal areas. mosley testing

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Novel endothelial cell markers in hepatocellular carcinoma

The expression and localisation of PODXL in human cells, tissues and organs have been investigated by the Human Protein Atlas consortium. According to antibody-based profiling, the protein is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus and seminal vesicle and according to RNA expression analysis, the PODXL transcripts are present in all analysed human tissues. Based on confocal microscopy, the protein is mainly localised to t… WebEndometrial epithelial cells are a very special cell type that plays a key role in switching between endometrial receptivity and nonreceptivity [36, 37]. In the absence of endometrial epithelial... miners bank ontonagonWebThe goal of my project was to define the roles of Podocalyxin (PODXL) in onset and progression of acute myeloid leukemia (AML). ... • ErbB2 activation induces endothelial cell-like functional ... mosley test

"WebApr 7, 2024 · The expression of PROX1 and vascular endothelial growth factor C (VEGFC) was found to be closely linked to PDPN. The expression of CD14 was found to be highly correlated with the distribution of markers for lymphangiogenesis (Figure 8A,B ), reflecting that CD14+ Mono/MΦ enter the vicinity of the glomerulus through newly forming … " - Podxl endothelial

Podxl endothelial

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WebUseful information about the protein provided by UniProt. Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive mo … WebJun 10, 2024 · It is unknown, however, how various lesions in PODXL contribute to these disparate disease pathologies. Here we generated two mouse stains: one that deletes …

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WebDec 30, 2024 · Results: Eleven cell types were identified, with immune-related cell types (T cells, natural killer cells, macrophages, and mast cells) distributed in the left (early) branch of the pseudotime tree, cancer stem cells, and CRISPLD2+ cells as intermediate cell types, and classic disease-related cell types (fibroblasts, smooth muscle cells, myofibroblasts, and … WebOct 10, 2014 · Conditional deletion of the Podxl locus in endothelial cells. ( A ) Schematic representation of the Podxl transgenic allele, floxed allele (Podxl F/F ) and deleted allele ( Podxl D F/F ).

WebFeb 1, 2007 · As can be seen in Fig. 2, normal pancreas only shows low levels of PODXL-1, probably derived from PODXL-1 expressed by endothelial cells. In contrast, high amounts of PODXL-1 protein at approximately 160 to 185 kD are found within PDACs. The calculated weight for PODXL-1 is 54 kD, ... WebENDOGLYCAN; EG HGNC Approved Gene Symbol: PODXL2 Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,629,185-127,672,802 (from NCBI) TEXT Description PODXL2 functions as a ligand on mononuclear cells for selectins (e.g., SELE; 131210) expressed on activated vessels ( Kerr et al., 2008 ). Cloning and Expression

WebOct 10, 2014 · PodxlΔECendothelial cells display mildly enhanced static adhesion to fibronectin but spread normally when plated on fibronectin-coated transwells. In contrast, PodxlΔECendothelial cells exhibit a severely impaired ability to spread on laminin and, to a lesser extent, collagen I coated transwells. WebPodocalyxin (PODXL) is a 145KDa sialoprotein abundantly expressed in the glycocalix of the intraglomerular kidney epithelial cells, essential in maintaining a normal renal function. …

WebEpithelial-mesenchymal transition (EMT) plays an important role in the progression of lung carcinoma. Podocalyxin (PODXL), which belongs to the CD34 family and regulates cell …

WebJul 2, 2024 · PODXL is encoded on chromosome 7q32-q33, and highly expressed by glomerular podocytes, vascular endothelium, hematopoietic cells and breast epithelial … mosley technologiesWebOct 1, 2004 · Only one case of HCC showed negative staining. PODXL was negative in all five normal livers and 8/10 paired cirrhotic tissues. Only two cirrhotic livers showed focal sinusoidal staining for PODXL. CD34, the other endothelial gene in cluster I, showed a staining pattern that was similar to PODXL . In contrast to the staining pattern of PODXL … mosley teamWebIn the kidney, PODXL functions primarily as an antiadhesive molecule in podocyte epithelial cells, regulating adhesion and cell morphology, and playing an essential role in the development and... miners beach falls michigan